Fig. 1.

Schematic representation of the mechanisms for allogeneic iPSC-derived cells to evade immunological rejection. Allogeneic iPSC-derived cell are recognized and eliminated by allo-reactive T cells through HLA class I and class II molecules. Deletion of HLA class I and class II are achieved by B2M and CIITA gene deletion, respectively. On the other hand, loss of HLA class I molecules, which function as ligands for NK inhibitory receptors, causes attack by NK cells. To avoid killing by NK cells, expressions of NK inhibitory ligands, such as HLA-C, HLA-E and CD47 have been reported