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Analysis of telomerase activity of single cells during the early development of the mouse embryo. Single cells from multicell samples were isolated by pronase digestion and Ca2+ depletion. (A) Illustration of the lineage of embryo development. GV, germinal vesicle; GVBD, germinal vesicle breakdown, M I, metaphase I; M II, metaphase II. (B) Telomerase activities. Telomerase-negative cells were excluded. (C) Percent of telomerase-positive cells.
