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. 2020 Sep 30;13:129. doi: 10.1186/s13045-020-00963-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Association of HDL cholesterol and apolipoprotein A1 levels with risk of hematological, breast, and respiratory cancer in individuals from the Copenhagen General Population Study. Hazard ratios and 95% confidence intervals (CIs) were obtained from Cox proportional hazards regression with restricted cubic splines multivariable adjusted for age, sex, body mass index, smoking status, cumulative tobacco consumption, alcohol intake, leisure-time physical activity, education, income, plasma triglycerides, lipid-lowering therapy, C-reactive protein, and baseline chronic disease (ischemic heart disease, chronic obstructive pulmonary disease, and diabetes). The median values of HDL cholesterol and apolipoprotein A1 were chosen as reference. The red line represents the hazard ratio and the dotted lines 95% CIs. Areas of light blue and purple represent the distribution of levels of HDL cholesterol and apolipoprotein A1, respectively. Numbers vary slightly due to exclusion of individuals with baseline cancer relevant for the specific cancer form. Hematological cancer included: non-Hodgkin lymphoma, Hodgkin’s lymphoma, multiple myeloma, leukemia, and myeloproliferative neoplasm. Respiratory cancer included: larynx and lung. HDL=high-density lipoprotein