Figure 5: FH+/2SC+ Immunophenotype: Renal Cell Carcinoma & Cutaneous Leiomyoma.
Representative images of an FH-deficient papillary renal cell carcinoma and a cutaneous leiomyoma in a patient with a germline pathogenic FH alteration are depicted (FH c.1097G>A, p.S366N; renal cell carcinoma: A-C; cutaneous leiomyoma: D-F). H&E stained images (A, D), corresponding results of FH (B, E) and 2SC (C, F) immunostaining are shown.