Table 2.
Expressions of the 10 antibodies in 94 cases of leiomyoma, ESS and ULMS
| Leiomyoma | Uterine leiomyosarcoma |
Endometrial stromal sarcoma |
p Value | |||
|---|---|---|---|---|---|---|
| Low grade | High grade | Low grade | High grade | |||
| Total | n=25 | n=28 | n=13 | n=19 | n=9 | |
| ER | % | % | % | % | % | <0.0001 |
| Score 0 | 12.0 | 71.4 | 92.3 | 21.1 | 55.6 | |
| Score 1–7 | 12.0 | 25.0 | 7.7 | 26.3 | 11.1 | |
| Score 8–12 | 76.0 | 3.6 | 0 | 52.6 | 3 (33.3) | |
| PR | <0.0001 | |||||
| Score 0 | 8.0 | 57.1 | 100 | 26.3 | 66.7 | |
| Score 1–7 | 12.0 | 28.6 | 0 | 0 | 11.1 | |
| Score 8–12 | 80.0 | 14.3 | 0 | 73.7 | 22.2 | |
| Desmin | 0.004 | |||||
| Score 0 | 4.0 | 39.3 | 38.5 | 55.6 | 37.5 | |
| Score 1–7 | 0 | 0 | 7.7 | 11.1 | 12.5 | |
| Score 8–12 | 96.0 | 60.7 | 53.8 | 33.3 | 50.0 | |
| SMA* | 0.001 | |||||
| Score 0 | 0 | 18.5 | 38.5 | 28.8 | 55.6 | |
| Score 1–7 | 4.0 | 0 | 0 | 22.2 | 11.1 | |
| Score 8–12 | 96.0 | 81.5%) | 61.5 | 50.0 | 33.3 | |
| CD10** | 0.005 | |||||
| Score 0 | 64.0 | 60.7 | 38.5 | 27.8 | 33.3 | |
| Score 1–7 | 32.0 | 17.9 | 30.8 | 11.1 | 11.1 | |
| Score 8–12 | 4.0 | 21.4 | 30.8 | 61.1 | 55.6 | |
| h-caldesmon* | 0.005 | |||||
| Score 0 | 8.0% | 25.9 | 23.1 | 55.6 | 55.6 | |
| Score 1–7 | 4.0 | 3.7 | 15.4 | 16.7 | 0 | |
| Score 8–12 | 88.0 | 70.4 | 61.5 | 27.8 | 44.4 | |
| Transgelin* | 0.036 | |||||
| Score 0 | 0 | 10.7 | 8.3 | 11.1 | 11.1 | |
| Score 1–7 | 0 | 17.9 | 8.3 | 33.3 | 0 | |
| Score 8–12 | 100 | 71.4 | 83.3 | 55.6 | 88.9 | |
| GEM*** | 0.056 | |||||
| Score 0 | 20.0 | 44.4 | 25.0 | 44.4 | 11.1 | |
| Score 1–7 | 28.0 | 25.9 | 0 | 33.3 | 33.3 | |
| Score 8–12 | 52.0 | 29.6 | 75.0 | 22.2 | 55.6 | |
| ASC1** | 0.30 | |||||
| Score 0 | 0 | 7.1 | 0 | 5.3 | 0 | |
| Score 1–7 | 20.0 | 17.9 | 0 | 5.3 | 0 | |
| Score 8–12 | 80.0 | 75.0 | 100 | 89.5 | 100 | |
| Stathmin1* | 0.001 | |||||
| Score 0 | 8.0 | 14.8 | 0 | 11.1 | 0 | |
| Score 1–7 | 52.0 | 11.1 | 0 | 22.2 | 0 | |
| Score 8–12 | 40.0 | 74.1 | 100 | 66.7 | 100 | |
Number (%) is shown. Score represents composite score based on intensity and % expression. χ2 test for p values
*
2 missing
**
1 missing
***
3 missing.
CD10, cluster of differentiation 10; ER, estrogen receptor; ESS, endometrial stromal sarcoma; GEM, Guanosine-5′- triphosphate (GTP)-binding protein overexpressed in skeletal muscle; and ASC1 solute carrier family 7; PR, progesterone receptor; SMA, smooth muscle actin; ULMS, uterine leiomyosarcoma.