Figure 1.

Flow diagram of the selection process. In total, 657 records were retrieved from PubMed, and an additional 35 records were found after snowballing in references of included records. Title and abstract screening resulted in the inclusion of 110 articles. One hundred fifty-nine articles were excluded because MDx were not performed on whole blood or with a short-term incubation step. There was no or a nonmolecular technique evaluated in 117 records. No language restrictions were set, but 32 articles had to be excluded because of a language barrier. After full-text screening, 85 more records were excluded, 47 because they only evaluated analytical performance of MDx and did not contain data on impact. The final search result yielded 25 eligible articles. Abbreviation: PBCBs, positive blood culture bottles.