Tissue	Species	CAA status	Secretion	Cancer	Experiment	Reference
Pancreas	Human	Dedifferentiation Dysregulated metabolism Delipidation	FFA, matrix remodeling factors, angiogenic factors	Enhanced migration Desmoplasia	Co-culture, RNA analysis, trans-well, transcriptome analysis	(Cai et al., 2019)
Pancreas	Human	Overexpression of Wnt signaling pathway	EMT inducing factors, WNT paracrine factors	EMT induction Enhanced migration	Wound healing assay, invasion assay, CM treatment, gene expression profile, RNA analysis	(Carbone et al., 2018)
Pancreas	Mouse	Dedifferentiation Lipolysis Fibrosis	FFA, HGF	Wnt5a secretion Enhanced FFA uptake Enhanced migration and invasion Chemoresistance	Organotypic fat invasion model, CM treatment, co-culture, FACS	(Okumura et al., 2017)
Breast	Mouse Human	Delipidation Reduced lipid droplet size and number	Protease, MMP11, IL-6, IL-1β, PAI1	Enhanced invasive phenotype	Co-culture, metastasis assay	(Dirat et al., 2011)
Breast	Mouse Human	Fibrosis Wnt/β-catenin activation FSP overexpression	Fibronectin, collagen I	Enhanced migration and invasion Enhanced CAF marker Enhanced FSP-1 Wnt3a secretion	Co-culture, fat pad injection, IHC, H&E staining, migration, invasion assay, glucose uptake assessment	(Bochet et al., 2013)
Breast	Human	IGFBP2 overexpression Delipidation	FFA, IGFBP2, ANGPTL4, IL6sR, IL8, insulin, leptin, MIF, PDGF, TGF-β, TNF-α	Enhanced MMP2 Decreased E-cadherin Enhanced metastasis	Co-culture, CM treatment, adipokine array, migration, invasion assay	(Wang et al., 2015)
Ovary	Mouse Human	Lipolysis Homing and lipid supply to tumor	FFA, IL-6, IL-8, MCP1, TIMP-1, adiponectin	Enhanced homing, migration, and invasion Overexpressed FABP4 Cytoplasmic lipid droplet accumulation	Co-culture, protein array, H&E staining, xenograft	(Nieman et al., 2011)
Ovary	Mouse Human	Lipid supply to tumor	IL8, IL6, FFA, leptin, adiponectin, prostaglandin, lipoxin, arachidonic acid	Enhanced chemoresistance Reduced cleaved PARP PI3K/Akt activation STAT3 activation	CM treatment, FACS, lipidomic analysis, lipid extraction, protein fractionation	(Yang et al., 2019)
Ovary	Human	Downregulation of Acetyl-CoA carboxylase	FFA, IL8	Enhanced metastasis Enhanced FFA uptake CD36 overexpression AMPK activation	Co-culture, CD36 inhibition, xenograft, H&E staining, TUNEL assay	(Ladanyi et al., 2018)
Prostate	Mouse Human	CCL7 and leptin overexpression Extraprostatic extension	CCL7, CXCR2, CXCR4, CXCL12, IL6, MMPs	Enhanced migration Enhanced invasion CCR3 (master regulator) CCR4	CM treatment, IHC, proteomic analysis, orthotopic transplantation, FACS, Mass spec	(Laurent et al., 2016)
Colon	Mouse	Lipolysis Support cancer cell growth and survival	FFA, glycerol	Upregulated mitochondrial fatty acid oxidation Enhanced oxygen consumption AMPK/autophagy activation Dedifferentiation	Co-culture, 3D organoids culture, xenograft, IHC, OCR assay, autophagy flux assay	(Wen et al., 2017)

CAA, cancer-associated adipocytes; FFA, free fatty acid; EMT, epithelial-mesenchymal transition; CM, conditioned media; HGF, hepatocyte growth factor; FACS, fluorescence-activated cell sorting; MMP, metalloproteinase; IL, interleukin; PAI1, plasminogen activator inhibitor 1; CAF, cancer-associated fibroblast; FSP-1, fibroblast-specific protein-1; IHC, immunohistochemistry; IGFBP2, insulin growth factor-binding protein 2; ANGPTL4, angiopoietin-like 4; MIF, macrophage migration inhibitory factor; PDGF, platelet-derived growth factor receptor; TGF-β, transforming growth factor-beta; TNF-α, tumor necrosis factor-α; MCP-1, monocyte chemoattractant protein-1; TIMP-1, tissue inhibitor of metalloproteinase 1; FABP4, fatty acid-binding protein 4; PARP, poly (ADP-ribose) polymerase; PI3K, phosphoinositide 3-kinase; Akt, protein kinase 8; STAT3, signaling transducer and activator of transcription 3; AMPK, AMP-activated protein kinase; CCL7, chemokine (C-C motif) ligand; CXCR, C-X-C motif chemokine receptor; CXCL, C-X-C motif chemokine ligand; CCR, C-C chemokine receptor; OCR, oxygen consumption rate.