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. 2020 Oct 1;34(19-20):1310–1315. doi: 10.1101/gad.339804.120

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© 2020 Li et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 4. — USP20 knockdown inhibits breast cancer lung metastasis. (A) The seeding of SUM159-M1a cells in the lung was monitored by bioluminescence imaging (BLI) every other day and was normalized to day 0. Data represent mean + SEM. (B) The growth of metastasis was monitored by BLI weekly. Data represent mean ± SEM. (C) Representative images of lungs with metastasis nodules (pointed by white arrows) at 28 d after injection. (D) Quantified results of lung metastasis nodules in each group. Each dot represents data from one individual mouse. Lines represent mean ± SEM. (ns) Nonsignificant, (*) P < 0.05, (**) P < 0.01, (***) P < 0.001 by one-tailed Student's t test.