Skip to main content
. 2020 Sep 17;11:1083. doi: 10.3389/fphar.2020.01083

FIGURE 2.

FIGURE 2

Oral-administration of LS-102 exhibited a dose-dependent relationship of cardioprotective effect in rat heart. (A) Representative image of TTC staining sections of the left ventricle. The viable tissue was stained as red area and the unstained pale areas were presumed to be infarcted tissue. (B) Bar chart of infarct size (%). (C) The activities of CK and LDH in serum were detected. (D) Representative high power views of I/R myocardial tissue slice showing neutrophil polymorphs flooding the infarcted area (thin arrow), infarcted cardiomyocytes appearing deeply eosinophilic with loss of cross striations (arrow head), prominent interstitial edema (thick arrow), RBCs in the interstitial spaces (open arrow). (E) Illustration of H&E staining of the myocardial tissue in different groups (200 × magnification). Sham and I/R, distilled water 8ml/kg; LS-102 2.5, LS-102 2.5 mg/kg; LS-102 5, LS-102 5 mg/kg; LS-102 10, LS-102 10 mg/kg. Data are shown as mean ± SEM, n = 8–10/group. ^^^P < 0.001, ^^P < 0.01, vs. Sham group, ***P < 0.001, **P < 0.01 vs. I/R group.