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. 2020 Sep 17;11:1083. doi: 10.3389/fphar.2020.01083

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Copyright © 2020 Chen, Chen, Wang, Yang, Zhou, Ding, Qing and Luo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of LS-102 on cell survival after H/R in H9c2 cells. (A) Effect of LS-102 on cell viability. (B) Cytotoxicity of LS-102 in H9c2 cells under normoxia condition. (C) Effects of LS-102 on CK and LDH activities in serum. (D) Representative DIC images of H9c2 cells. (E) Effect of LS-102 on H/R-induced H9c2 cell apoptosis. Flow cytometry was used to detect apoptotic cells which were calculated the sum of the Q2 and Q3 quadrant. (F) Using western blot analysis to determine the protein expression of Bcl-2, Bax, and Cleaved-Caspase-3. The ratio of Bcl-2 to Bax was calculated and normalized to the Normal group. Values are means ± SEM of three or four independent experiments. ^^^P < 0.001 vs. Normal group. *P < 0.05, **P < 0.01 and ***P < 0.001 vs. H/R group.