Table 2.

Confusion Matrix Comparing Phenotype Classification Derived by the Gradient-Boosting Machine (Clinical Classifier) Model with Original LCA-derived Classification in the Primary Validation Data Set (SAILS)^*

	LCA-assigned Hyperinflammatory Class	LCA-assigned Hypoinflammatory Class	Total
Clinical classifier–derived hyperinflammatory class	175 (sensitivity 0.63)	8	183
Clinical classifier–derived hypoinflammatory class	102	460 (specificity 0.98)	562
Total	277	468	—

Definition of abbreviations: LCA = latent class analysis; SAILS = Statins for Acutely Injured Lungs from Sepsis.

^*Probability cutoff of ≥0.5 to assign phenotype.