Table 3.
Region-based Association Tests within Each Fine-Mapping Region
| Chr | Start Position | End Position | P Value | No. of Rare Markers | Nearest Gene(s) | Window ID |
|---|---|---|---|---|---|---|
| 1 | 196762063 | 196763063 | 2.97 × 10−5* | 1 | CFH, CHFR3 | 1 |
| 1 | 199359563 | 199360536 | 6.76 × 10−5* | 4 | LINC02789, LOC400600 | 2 |
| 5 | 169911224 | 169912224 | 1.01 × 10−4† | 6 | DOCK2, INSYN2B | 3 |
| 5 | 167726224 | 167727224 | 2.44 × 10−4† | 6 | TENM2 | 4 |
Definition of abbreviation: Chr = chromosome.
Genetic variants (minor allele frequency < 0.01) were aggregated in 1-kb sliding windows to examine the association with lung function adjusting for covariates using SKAT-O. Suggestive windows were reported within 1q32 and 5q35.1 regions.
*
Chromosome 1 (after multiple test correction): adjusted P value = 2.28 × 10−5, adjusted suggestive P value = 4.6 × 10−4.
†
Chromosome 5 (after multiple test correction): adjusted P value = 2.64 × 10−5, adjusted suggestive P value = 5.3 × 10−4.