Table 2. Prognostic accuracy of difference score in predicting the in-hospital mortality and the difference with AUROC of MEWS.
| AUROC (95% CI) | Age-adjusted AUROC (95% CI) | Cut-off | SEN (%) | SPE (%) | NNPV (%) | PPV (%) | Difference with AUROC of MEWS (95% CI) | P | |
|---|---|---|---|---|---|---|---|---|---|
| APACHE II | 0.937 [0.877–0.995] | 0.0943 [0.886–0.984] | 16.5 | 91.9 | 87.4 | 98.3 | 57.6 | −0.025 [−0.075 to 0.026] | 0.828 |
| SOFA | 0.926 [0.877–0.975] | 0.927 [0.87–0.969] | 5.5 | 81.1 | 89.4 | 96.2 | 58.8 | −0.013 [−0.049 to 0.024] | 0.748 |
| PSI | 0.927 [0.898–0.986] | 0.934 [0.879–0.976] | 113.5 | 91.9 | 86.4 | 98.3 | 55.7 | −0.015 [−0.065 to 0.035] | 0.735 |
| CURB-65 | 0.845 [0.740–0.951] | 0.833 [0.739–0.912] | 1.5 | 83.8 | 73.7 | 96.1 | 37.4 | 0.064 [0.002–0.125] | 0.015 |
| MEWS | 0.913 [0.864–0.941] | 0.913 [0.853–0.960] | 4.5 | 67.6 | 94.5 | 94.1 | 78.1 | — | |
| SIRS criteria | 0.696 [0.616–0.776] | 0.776 [0.700–0.842] | 0.5 | 89.9 | 50.0 | 96.1 | 25.0 | 0.218 [0.156–0.279] | <0.001 |
| qSOFA | 0.886 [0.804–0.969] | 0.899 [0.818–0.956] | 1.5 | 73.0 | 95.0 | 95.0 | 73.0 | 0.024 [−0.029 to 0.076] | 0.174 |
Note:
APACHE II, acute physiology and chronic health evaluation II; SOFA, sequential organ function assessment; qSOFA, quick sequential organ function assessment; PSI, pneumonia severity index; CURB-65, the combination of confusion, urea, respiratory rate, blood pressure, and Age ≥65; MEWS, modified early warning score; SIRS, systemic inflammatory response syndrome; AUROC, area under the receiver operating characteristic curve; SEN, sensitivity; SPE, specificity; NPV, negative predictive value; PPV, positive predictive value.