Skip to main content
. 2020 Oct;63(4):436–443. doi: 10.1165/rcmb.2020-0034MA

Figure 1.

Figure 1.

ABCA3 (ATP-binding cassette transporter A3) protein processing results for A549/ABCA3−/− cells that express ABCA3 wild type (WT), p.E292V, or p.L101P are similar to results from adenoviral transduced A549 and alveolar type II (ATII) cells. IB of type I (mistrafficking) mutant p.L101P demonstrates a single, uncleaved 220-kD band in all three cell-model systems. Protein processing of type II (impaired phospholipid transport) mutant p.E292V is similar to that of ABCA3 WT. These experiments were performed three times with similar results.