Figure 3.

The results of in vivo efficacy of daptomycin (DAP) in combination with ampicillin (AMP), ertapenem (ERT), or ceftaroline (CPT) in the rat infective endocarditis model. CPT (40 mg/kg) and DAP (45.3 mg/kg; both by 30-minute intravenous infusion via the jugular vein, every 8 hours for 3 days) were used against Enterococcus faecium strain R497. Horizontal lines represents geometric mean colony-forming unit (CFU) counts. Previously published experimental efficacious doses of AMP (333.33 mg/kg/8 h), ERT (20 mg/kg/8 h), and CPT (40 mg/kg/8 h) for 3 days were used. Controls represent no antibiotic treatment.