Table 1.

Animal Model Results

Treatmenta	Vegetation, Mean (SD), Log10 CFUs/g	Comparison	Difference Between Means (CFU/g)b	P Valuec
DAP + AMP	1 (1)	Versus baseline untreated controls (5.4 [0.7])	−4.4 (0.5)	<.001
DAP + CPT	3.3 (1)		−2.1 (0.8)	.03
DAP	4.6 (1)		−0.7 (0.7)	.31
CPT	6.4 (0.1)		+0.9 (0.3)	.01
DAP + AMP	1 (1)	Versus DAP + CPT	−2.3 (0.9)	.03
		Versus DAP	−3.6 (0.8)	<.001
		Versus CPT	−5.3 (0.5)	<.001
		Versus AMP	−4.2 (0.7)	<.001
		Versus DAP + ERTd	−4.7 (0.9)	<.001
DAP	4.6 (1)	Versus CPT	−1.7 (0.7)	.04
AMP	5.2 (1)	Versus CPT	−1.1 (0.7)	.13

Abbreviation: AMP, ampicillin; CFUs, colony-forming units; CPT, ceftaroline; DAP, daptomycin; ERT, ertapenem.

^a All antibiotics were administered daily day for 3 days against Enterococcus faecium strain R497. The dosages were as follows: DAP, 45.3 mg/kg (7-hour intravenousinfusion every 24 hours); AMP, 333 mg/kg (30-minute infusion every 8 hours); and CPT, 40 mg/kg (30-minute infusion every 8 hours).

^b Negative values in this column indicate that CFU counts were lower than in the comparison group (control or other treatment group); positive values, that CFU counts were higher than in controls.

^c Data were log-transformed, and unpaired t tests were performed to obtain P values.

^d ERT dosage: 20 mg/kg (infusion for 30 minutes, every 8 hours for 3 days).

NOTE: The first 4 rows are compared with controls.