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. 2020 Oct;61(10):1308–1319. doi: 10.1194/jlr.RA119000479

Fig. 1.

Fig. 1.

AlloP decreases in the brain with age, and its restoration improves working memory. A–C: LC/MS quantification of PRG (A), 5α-dihydroprogesterone (B), and AlloP (C) in the cerebral cortex from young (3 months), middle-aged (12 months), and old mice (24 months) (n = 6 per group; one-way ANOVA). D: Illustration of the RAWM. Orange boxes indicate incorrect arms, and the yellow box indicates the target arm containing the escape platform. E–G: Performance in the RAWM in young (3 months), old (24 months), and old mice treated with AlloP. E: Average velocity of the mice in each group while in the RAWM. F: Average latency from the starting arm to the target platform. G: Average entries into incorrect arms. E–G: Data represent the average of eight trials per day over 3 days (n = 9 per group; two-way ANOVA and Tukey HSD pairwise comparisons). *P < 0.05. Statistics were adjusted for multiple comparisons. Only significant differences are depicted in the figure. Data are presented as mean ± SEM.