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. 2020 Oct;61(10):1308–1319. doi: 10.1194/jlr.RA119000479

Fig. 5.

Fig. 5.

IL-6 increases in the brain with age, and its administration to young mice reduces AlloP synthesis and increases CORT synthesis. A, B: Cerebral cortex tissues from young (3 months), middle-aged (12 months), and old (24 months) mice. A: Percent mRNA expression of IL-6 across age relative to young (n = 8 per group; one-way ANOVA). B: Levels of IL-6 (picograms per milligram of protein) in the cortex across age (n = 6 per group; one-way ANOVA). C: Experimental design of saline or IL-6 infusions to the mouse brain. Saline or IL-6 was loaded into an osmotic pump that was coupled to a cannula and inserted into the lateral ventricle of the brain in young (4 months) mice. The osmotic pump delivered saline or IL-6 (100 ng/day) continuously for 14 days. D: Levels of IL-6 (pg/mg protein) in the cortex following Saline or IL-6 intracerebroventricular infusion. E, F: AlloP and CORT levels in the cortex of young mice following 2 weeks of intracerebroventricular infusions of either saline or IL-6 (100 ng/day) to the lateral ventricle of the brain (n = 8 per group, unpaired Student’s t-test, *P < 0.05). Statistics were adjusted for multiple comparisons. Only significant differences are depicted in the figure. Data are presented as mean ± SEM.