Table 1.

Organ and system involvement in mast cell activation syndrome. Conditions highlighted in bold are also seen in Covid-19 acute infection and/or post-infectious syndrome.

Organ/system	Symptom/finding
Constitutional	Fatigue, fevers, chills, weight loss, weight gain
Ears, nose and throat	Conjunctivitis, rhinitis, sinusitis, dysosmia/anosmia, tinnitus, hearing loss, dysgeusia/ageusia, sore throat
Neurologic	Headaches, migraines, brain fog, anxiety, depression, insomnia, seizures
Cardiovascular	Chest pain, palpitations, hypotension
Pulmonary	Cough, dyspnoea, wheezing
Urogenital	Frequency, urgency, dysuria, pelvic pain
Oesophageal	Heartburn, dysphagia, globus, chest pain
Stomach	Dyspepsia, nausea, vomiting
Small intestine/colon	Bloating, food intolerance, abdominal pain, diarrhoea, constipation
Hepatic	Elevated transaminases, hepatomegaly
Salivary Glands	Swelling
Lymphatics	Lymphadenopathy
Dermatologic	Flushing, pruritis, urticaria, haemangiomas, nodules, rashes, alopecia
Musculoskeletal	Myalgias, arthralgias, oedema