Table 1.

Red Flags for Malignancy

Signs, Symptoms, and Concerns
History of malignancy
Strong clinical suspicion
Unexplained/unintentional weight loss
Age >50 years
Failure to improve with 4-6 weeks of treatment
Pain at rest
Malaise
Fever
Reduced appetite
Rapid fatigue
Progressive symptoms
Multiple cancer risk factors
Paraparesis

Note: Adapted from Verhagen et al.⁶