Skip to main content
. 2020 Oct 1;15(10):e0238578. doi: 10.1371/journal.pone.0238578

Table 1. Five neuronal regeneration-related genes with significant changes in the spiral ganglion after kainate treatment.

Fold change vs. control
Gene Protein Functions in neurons 5 h 24h 72h
Nlgn2 Neuroligin-2 Involved in synapse formation, maturation and specification -1.6 2.6* -1.0
Ntrk3 Neurotrophic tyrosine kinase receptor type 3 (alias TrkC) Promotes spiral ganglion neuronal survival in the inner ear 1.2 3.3* -0.8
Rgmb Repulsive guidance molecule family member B Regulates neurite growth and axonal guidance; contributes to the patterning of the developing nervous system. -1.6 2.4* -0.9
Sema7a Semaphorin7A Involved in neuron migration and neurite growth -1.9 4.5* -1.4
Syt8 Synaptotagmin 8 Unclear 1.3 -1.8* -1.3

* p < 0.005 as compared to the controls.

Negative numbers indicate downregulation and positive numbers indicate upregulation of gene expression relative to untreated controls.