Table 1. Five neuronal regeneration-related genes with significant changes in the spiral ganglion after kainate treatment.
Fold change vs. control | |||||
---|---|---|---|---|---|
Gene | Protein | Functions in neurons | 5 h | 24h | 72h |
Nlgn2 | Neuroligin-2 | Involved in synapse formation, maturation and specification | -1.6 | 2.6* | -1.0 |
Ntrk3 | Neurotrophic tyrosine kinase receptor type 3 (alias TrkC) | Promotes spiral ganglion neuronal survival in the inner ear | 1.2 | 3.3* | -0.8 |
Rgmb | Repulsive guidance molecule family member B | Regulates neurite growth and axonal guidance; contributes to the patterning of the developing nervous system. | -1.6 | 2.4* | -0.9 |
Sema7a | Semaphorin7A | Involved in neuron migration and neurite growth | -1.9 | 4.5* | -1.4 |
Syt8 | Synaptotagmin 8 | Unclear | 1.3 | -1.8* | -1.3 |
* p < 0.005 as compared to the controls.
Negative numbers indicate downregulation and positive numbers indicate upregulation of gene expression relative to untreated controls.