Table 2. Four genes with significant changes at two different time points after kainate treatment.
| Fold change vs. control | ||||
|---|---|---|---|---|
| Gene | Protein | Function in neurons | 5 h | 24 h |
| Elavl4 | ELAV-like protein 4 | Control neuronal development and functions by regulating RNA metabolism. | -3.4* | 4.2* |
| Ppp1r1c | protein phosphatase 1, regulatory subunit 1C | Inhibit neurite growth in primary sensory neurons by maintaining TGF-ß/Smad signaling | -3.4* | 4.0* |
| Psd2 | pleckstrin and Sec7 domain-containing protein 2 | Regulate axon transport and axon growth in neurons; interact with interferon γ pathway. | -2.4* | 3.1* |
| Syn1 | synapsin I | Control the transition of synaptic vesicles, regulate neurite outgrowth, and promote neuronal survival. | -2.9* | 4.3* |
* p < 0.005 as compared to the controls.
Negative numbers indicate downregulation and positive numbers indicate upregulation of gene expression relative to untreated controls.