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. 2020 Oct 1;15(10):e0240022. doi: 10.1371/journal.pone.0240022

Fig 3. Effect of TC-HT on Aβ-induced cytotoxicity in SH-SY5Y cells.

Fig 3

(A) The cell viability of SH-SY5Y cells treated with 25 or 50 μM Aβ for 4 days. (B) The TC or HT pretreatment and post-treatment at 42.5°C temperature setting were applied to the cells before or after 50 μM Aβ administration, and the cell viability was measured by MTT assay 4 days after treatment. The TC or HT treatment was applied 4 h before the Aβ administration for the pretreatment group and 1 h after Aβ administration for the post-treatment group. (C) Representative light microscopy images of SH-SY5Y cells after treatment. The integrity of the cells was destructed by Aβ, and the TC post-treatment caused the protective effect and retained the cell morphology. Scale bar = 100 μm. Data represent the mean ± standard deviation (n = 3). ***P < 0.001.