Table 1. An overview of the parameters and variables.
symbol | unit | description |
---|---|---|
Nt | - | number of recrudescence events at time t post treatment interruption |
Vt | copies mL−1 | VL at time t post treatment interruption |
Ti | d | time of the i-th successful reactivation event. |
g | d−1 | exponential growth rate of the VL |
v0 | copies mL−1 | average initial viral concentration caused by a single successful reactivation |
λ | d−1 | recrudescence rate, the number of latently infected cells that successfully reactivate per day. |
K(θ) | - | cumulant-generating function of the viral load Vt. |
κ1 | copies mL−1 | first cumulant, equal to the expectation of the VL (). |
κ2 | copies2mL−2 | second cumulant, equal to the variance of the VL (Var[Vt]). |
copies mL−1 | conditionally deterministic approximation of the viral load process Vt. | |
ℓ | copies mL−1 | limit of detection of the VL assay. |
τ | d | viral rebound time, satisfies the equation Vτ = ℓ |
S(t) | - | fraction of subjects in remission at time t post treatment interruption |
f(t; λ, g, v0, ℓ) | d−1 | approximation of the probability density function of the rebound time τ |
d | first recrudescence time extrapolated from the rebound time using the growth rate and the initial VL, assuming simple exponential growth. | |
tART | d | days post infection that ART was initiated |
Gi | d−1 | random, clone-specific exponential growth rate. |
σG | d−1 | standard deviation of the growth rates Gi of the clones comprising the SIV reservoir |
See also Table 2 for additional parameters of the Bayesian mixed-effects model.