Skip to main content
. 2020 Oct 1;16(10):e1008241. doi: 10.1371/journal.pcbi.1008241

Table 1. An overview of the parameters and variables.

symbol unit description
Nt - number of recrudescence events at time t post treatment interruption
Vt copies mL−1 VL at time t post treatment interruption
Ti d time of the i-th successful reactivation event.
g d−1 exponential growth rate of the VL
v0 copies mL−1 average initial viral concentration caused by a single successful reactivation
λ d−1 recrudescence rate, the number of latently infected cells that successfully reactivate per day.
K(θ) - cumulant-generating function of the viral load Vt.
κ1 copies mL−1 first cumulant, equal to the expectation of the VL (E[Vt]).
κ2 copies2mL−2 second cumulant, equal to the variance of the VL (Var[Vt]).
V˜t copies mL−1 conditionally deterministic approximation of the viral load process Vt.
copies mL−1 limit of detection of the VL assay.
τ d viral rebound time, satisfies the equation Vτ =
S(t) - fraction of subjects in remission at time t post treatment interruption
f(t; λ, g, v0, ) d−1 approximation of the probability density function of the rebound time τ
T^1 d first recrudescence time extrapolated from the rebound time using the growth rate and the initial VL, assuming simple exponential growth.
tART d days post infection that ART was initiated
Gi d−1 random, clone-specific exponential growth rate.
σG d−1 standard deviation of the growth rates Gi of the clones comprising the SIV reservoir

See also Table 2 for additional parameters of the Bayesian mixed-effects model.