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Diagram showing the basic mechanism of visceral pain and hyperalgesia. 5‐HT, 5‐hydroxytryptamine; ASIC, acid‐sensing ion channel; ATP, adenosine triphosphate; BK, bradykinin; CGRP, calcitonin gene related peptide; DRASIC, dorsal root acid sensing ionic channel; DRG, dorsal root ganglion; NGF, nerve cycloxygenase; NMDA, N‐methyl‐D‐aspartate; P, pain neurons; PG, prostaglandin; SP, substance‐P; T, tactile; TRPV1, transient receptor potential vanilloid type 1
