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Analysis of motor deficits. The impairment of muscle and motor coordination of KI rats was determined using the Rotarod test at 4, 8 and 12 mo of age (A, n = 16‐19 for WT, n = 22‐24 for KI, female). The grip force of the limbs was measured by the grip test (B, n = 16‐19 for WT, n = 22‐24 for KI, female). The female KI rats developed hind limb paralysis by 13 mo of age (C, n = 25). NS, no significant difference; *P < .05, **P < .01, ***P < .001
