Table 1.
JB’s demographic and neuropsychological profile
Visit number (Year) | |||||||||
---|---|---|---|---|---|---|---|---|---|
Scoring | Controls m (SD) | 1 (2009) | 2 (2011) | 3 (2013) | 4 (2014) | 5 (2015) | 6 (2016) | 7 (2018) | |
Age at testing | 67 | 69 | 71 | 72 | 73 | 74 | 76 | ||
CDR | 0.5 | 0.5 | 0.5 | 0.5 | 1 | 1 | 1 | ||
MMSE | Max. 30 | 29.5 (0.7) | 28 | 29 | 27 | 27 | 27 | 26 | 27 |
Visuospatial processing | |||||||||
Benson complex figure - copy | Max. 17 | 15.1 (1.7) | 15 | 16 | NC | 11* | 14 | 16 | 16 |
VOSP Number Location | Max. 10 | 9.1 (1.0) | 10 | 10 | NC | 10 | 10 | 10 | 10 |
Episodic memory | |||||||||
CVLT short delay free recall | Max. 9 | 7.9 (1.6) | 6 | 6 | 5 | 5 | 5 | 4* | 3* |
CVLT long delay free recall | Max. 9 | 7.3 (1.6) | NC | 7 | 5 | 1* | 0* | 2* | 2* |
CVLT recognition | Max. 9 | 8.7 (0.9) | 7 | 9 | 5* | 4* | 5* | 7 | 7 |
Benson complex figure - delay | Max. 17 | 10.9 (3.9) | NC | 8 | NC | 7 | 5 | 7 | 0* |
Executive functioning | |||||||||
Digit span - forward | Max. 9 | 6.9 (1.2) | 9 | 9 | 9 | 8 | 7 | 8 | 9 |
Digit span - backward | Max. 8 | 4.9 (1.1) | 5 | 7 | 6 | 7 | 6 | 5 | 5 |
Stroop | # correct | 88.3 (18.5) | 84 | 84 | NC | 73 | 68 | 80 | 69 |
Trails | Max. 14 | 13.9 (0.9) | NC | 14 | 14 | 14 | 14 | 14 | 14 |
Language | |||||||||
Syntax comprehension | % correct | 98.5 (1.8) | 100 | 100 | 100 | NC | 96 | 100 | 100 |
WAB Sequential Commands | Max. 80 | 80 (0) | 80 | 62 | 80 | 80 | 80 | 80 | NC |
WAB Auditory Word Recognition | Max. 60 | 60 (0) | 60 | 60 | 60 | 60 | 60 | 60 | NC |
WAB Spontaneous Speech | Max. 20 | 20 (0) | 20 | 20 | 20 | 20 | 20 | 20 | NC |
WAB Repetition | Max. 100 | 99.5 (0.9) | 100 | 100 | NC | 100 | 100 | 100 | NC |
PPVT | Max. 16 | 15.7 (0.6) | 16 | 14* | NC | 14* | 13* | 13* | 11* |
Verbal fluency - semantic | # correct | 21.2 (3.6) | 14 | 12* | 9* | 11* | 14 | 9* | 6* |
Verbal fluency - phonemic | # correct | 16.6 (6.8) | 6 | 13 | 9 | 12 | 11 | 11 | 8 |
BNT | Max. 15 | 14.4 (0.7) | 12* | 13 | 13 | 11* | 11* | 6* | 8* |
Note.
= more than 2 standard deviations below the mean of controls; NC = not collected, CDR = Clinical Dementia Rating Scale; MMSE = Mini-Mental State Examination; VOSP = Visual Object and Space Perception Battery; CVLT = California Verbal Learning Test; WAB = Western Aphasia Battery; PPVT = Peabody Picture Vocabulary Test; BNT = Boston Naming Test