Figure 1.

Determinants of ACE2 concentration

(A) Ranked demographic and clinical determinants. (B) Phenotypic and genetic effects of clinical factors on plasma ACE2 concentration. BMI effect is reported per 5 kg/m² increase. Blood pressure effect was reported per 10 mm Hg increase. LDL effect was reported per 1 mmol/L increase. Diabetes effect was reported versus those without diabetes for phenotypic analysis and in terms of 1 log odd unit increase for genotypic analysis. Smoking effect was reported in comparison to those without smoking history (phenotypic analysis) and in terms of 1 log odd unit increase (genotypic analysis). ACE2=angiotensin-converting enzyme 2. BMI=body-mass index.