Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Sep 10;11(1):237–249. doi: 10.1080/19491034.2020.1815410

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 2. — Effects of uniaxial stretching and actin depolymerization on nuclear membrane ruptures. (a) Bar graph showing percentages of wild-type (WT) mouse embryonic fibroblasts (MEFs) and triple-knockout (TKO) MEFs with nuclear membrane ruptures under static conditions and with uniaxial stretching. TKO MEFs lack all nuclear lamins. Black circles indicate percentages of cells with nuclear membrane ruptures in three independent experiments. Numerical ratios show the total number of cells with nuclear membrane ruptures in all three experiments over the total number of cells examined. ***P < 0.0005; ns, nonsignificant. (b) Bar graph showing that cytochalasin D reduces the percentage of nuclear membrane ruptures in TKO MEFs cultured under static conditions and with uniaxial stretching. Numerical ratios show the total number of cells with nuclear membrane ruptures over the total number of cells examined. ***P < 0.0001. Reproduced with permission from Chen et al. [16].