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. 2020 Sep 29;4:PO.20.00097. doi: 10.1200/PO.20.00097

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FIG 2. — Circulating Dickkopf-1 (DKK1) levels are elevated in patients with metastatic castration-resistant prostate cancer (mCRPC) and inversely correlate with tumoral [¹⁸F]dihydrotestosterone (FDHT) uptake. (A) Serum prostate-specific antigen (PSA) and (B) serum DKK1 quantitated in patients with mCRPC who underwent FDHT positron emission tomography (PET) imaging. Patients are grouped on the basis of total FDHT uptake of all metastatic lesions above (high) and below (low) the median for the cohort. (C) Plasma DKK1 protein quantitated in healthy control (HC) men and patients with mCRPC. (D) Plasma DKK1 protein quantitated in treatment-naive patients with metastatic castrate-sensitive prostate cancer and matched samples from onset of mCRPC.