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. 2020 Sep 29;4:PO.20.00097. doi: 10.1200/PO.20.00097

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© 2020 by American Society of Clinical Oncology

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FIG 4. — Dickkopf-1 (DKK1) can contribute to immune evasion through modulation of natural killer (NK) cell activity. (A) CIBERSORT2 immune cell composition analysis of the Stand Up to Cancer/Prostate Cancer Foundation metastatic castration-resistant prostate cancer cohort (n = 212) was carried out. DKK1 low and high groupings represent the bottom and top quartiles of DKK1 mRNA expression. (B) and (C) Mean tumor volumes and SEM are plotted. P values from two-way repeated-measures analysis of variance with Sidak’s multiple comparisons. Representative data from one of two independent experiments are shown. SCID, severe combined immunodeficient.