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Association between clonal hematopoiesis and response to immune checkpoint blockade. (A) Clinical response and (B) maximum severity of immune-related adverse events (irAEs) stratified by age. (C) Clinical response and (D) maximum severity of irAEs stratified by clonal hematopoiesis of indeterminate potential (CHIP) status (no CHIP, CHIP with variant allele frequency [VAF] > 0.01, CHIP with VAF 0.01-0.1, and CHIP with VAF > 0.1).
