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. 2020 Sep 28;4:PO.20.00015. doi: 10.1200/PO.20.00015

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© 2020 by American Society of Clinical Oncology

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FIG 1. — Multidimensional scaling analysis of differential DNA methylation between renal cell carcinoma (RCC) subtypes and oncocytoma. Multidimensional scaling plot illustrating dissimilarity between RCC subtypes (pRCC, ccRCC, and chRCC), NKP, and oncocytoma in terms of their DNA methylation profiles. The cytosine-phosphate-guanine sites used for multidimensional scaling (n = 46,530) include all those that were used by a diagnostic model that was trained on TCGA data to distinguish RCC subtypes. Unfilled circles represent TCGA patient samples. Square points represent centroids for each of the TCGA sample groups (pRCC, ccRCC, chRCC, and NKP). Filled circles represent Stanford study patient samples. ccRCC, clear-cell renal cell carcinoma; chRCC, chromophobe renal cell carcinoma; KICH, kidney chromophobe (TCGA study abbreviation); KIRC, kidney renal clear cell carcinoma (TCGA study abbreviation); KIRP, kidney renal papillary cell carcinoma (TCGA study abbreviation); NKP, normal kidney parenchyma; pRCC, papillary renal cell carcinoma; RN, renal neoplasm; TCGA, The Cancer Genome Atlas.