Table 2.
The pharmacokinetic parameters of osimertinib after pretreated with avitinib in rats (n = 6)
| Parameter | Unit | Multiple dose | CV% | Single dose | CV% | Control | CV% |
|---|---|---|---|---|---|---|---|
| AUC(0‐t) | ug/L*hour | 1019.49 ± 240.07* | 23.5 | 1255.82 ± 419.43* | 33.4 | 534.50 ± 142.84 | 26.7 |
| AUC(0‐∞) | ug/L*hour | 1035.47 ± 247.53* | 23.9 | 1283.21 ± 429.78* | 33.5 | 539.32 ± 144.35 | 26.8 |
| MRT(0‐t) | hour | 11.17 ± 0.93* | 8.3 | 10.57 ± 0.71* | 6.8 | 8.04 ± 1.10 | 13.6 |
| MRT(0‐∞) | hour | 11.65 ± 1.13* | 9.7 | 11.28 ± 0.88* | 7.8 | 8.28 ± 1.13 | 13.6 |
| t1/2 | hour | 5.12 ± 0.92 | 17.9 | 5.74 ± 0.67* | 11.7 | 4.08 ± 0.98 | 24.1 |
| Tmax | hour | 8.00 ± 0.00* | 0 | 6.80 ± 1.79 | 26.3 | 4.60 ± 2.41 | 52.3 |
| Vz/F | L/kg | 75.55 ± 27.50 | 36.4 | 71.70 ± 28.01 | 39.1 | 112.45 ± 24.31 | 21.6 |
| CLz/F | L/h/kg | 10.27 ± 3.25* | 31.7 | 8.65 ± 3.20* | 37 | 19.76 ± 5.84 | 29.6 |
| Cmax | ug/L | 85.35 ± 23.93* | 28 | 88.30 ± 23.65* | 26.8 | 51.47 ± 10.74 | 20.9 |
*
P < 0.05 indicates significant differences from the control group.