Table 2.
Cytotoxicity and antiparasitic IC50 values for test compounds along with calculated selectivity indices.
| Compound | Cytotoxicity IC50 (μM) | Anti-parasitic IC50 (μM) | Selectivity index (SI)d |
|---|---|---|---|
| JS-1-09 | 64.05a | 1.21b | 52.9 |
| JS-2-20 | 62.65a | 10.92b | 5.7 |
| JS-2-35 | 59.17a | 10.49b | 5.6 |
| JS-2-49 | 65.49a | 12.09b | 5.4 |
| GMG-1-09 | 450.47** | 32.24c | 14.0 |
a
Cytotoxicity IC50 value against human foreskin fibroblasts (HFF); **Cytotoxicity IC50 value against human ileocecal adenocarcinoma (HCT-8) cells.
b
Anti-Toxoplasma IC50.
c
Anti-Cryptosporidium IC50.
d
Selectivity Index (SI) = Cytotoxicity IC50/Anti-parasitic IC50.