Table 2a.

Hazard ratios from Multivariate Cox regressions models indicating the incidence of dementia by levels of CR Index, using an adaptation of the previously published thresholds (Nucci et al., 2012)

	CR Index	Hazard ratio (95% CI)	p-value	PERM
Model 1	Low	1[Reference]
(Sex + Marital status)	Medium	0.65(0.53–0.81)	<0.001	…
	High	0.48(0.36–0.64)	<0.001	…
Model 2	Low	1[Reference]
(Model 1 + Wealth)	Medium	0.71(0.56–0.88)	0.002	17%
	High	0.60(0.44–0.81)	0.001	23%
Model 3	Low	1[Reference]
(Model 1 + Smoke)	Medium	0.67(0.53–0.83)	<0.001	6%
	High	0.50(0.37–0.67)	<0.001	4%
Model 4	Low	1[Reference]
(Model 1 + Depressive symptoms)	Medium	0.68(0.55–0.85)	0.001	9%
	High	0.53(0.40–0.71)	<0.001	10%
Model 5	Low	1[Reference]
(Model 1 + CHD)	Medium	0.66(0.53–0.82)	<0.001	3%
	High	0.49(0.37–0.65)	<0.001	2%
Model 6	Low	1[Reference]
(Model 1 + Diabetes)	Medium	0.66(0.53–0.82)	<0.001	3%
	High	0.49(0.37–0.65)	<0.001	2%
Model 7	Low	1[Reference]
(Model 1 + Stroke)	Medium	0.66(0.53–0.82)	<0.001	3%
	High	0.49(0.37–0.65)	<0.001	2%
Model 8	Low	1[Reference]
(Model 1 + Hypertension)	Medium	0.66(0.53–0.81)	<0.001	3%
	High	0.49(0.37–0.64)	<0.001	2%
Model 9	Low	1[Reference]
(Model 1 + All covariates)	Medium	0.73(0.59–0.92)	0.008	23%
	High	0.65(0.48–0.89)	0.008	33%

CHD: Coronary Heart Disease, CR: Cognitive Reserve, PERM: Percentage of excess risk mediated