Table 1.
Characteristics of Patients with EO-ICP, LO-ICP, Light to Moderate Drinking with CP, and ACP
| Light to Moderate | ||||||
|---|---|---|---|---|---|---|
| Characteristic | EO-ICP (n=61) | LO-ICP (n=69) | Drinking with CP (n=308) | ACP (n=225) | P Value (Overall) | P Value (EO-ICP vs LO-ICP) |
| Sex, male , No. (%) | 23 (38) | 13(19) | 164(53) | 165 (73) | <.001 | .02 |
| Age at symptom onset, median, (IQR) | 20 (12–27) | 58 (46–67) | 47 (35–61) | 44 (36–52) | <.001 | <.001 |
| Age at diagnosis, median (IQR) | 26.5 (18–37) | 60 (48–68) | 52 (40–63) | 47 (41–55) | <.001 | <.001 |
| Age at enrollment, median (IQR) | 30.1 (20.8–40.0) | 64.3 (52.1–70.9) | 54.4 (42.4–65.6) | 50.8 (44.0–57.4) | <.001 | <.001 |
| BMI, current, median (IQR) | 25.0 (20.6–28.7) | 25.8 (22.4–29.1) | 24.2 (21.4–27.4) | 23.4 (20.6–26.2) | .003 | .19 |
| BMI, maximum, median (IQR) | 29.5 (25.1–36.5) | 31.0 (27.8–33.5) | 28.4 (25.5–32.7) | 29.1 (25.0–32.8) | .05 | .23 |
| History of smoking, No. (%)a | <.001 | .23 | ||||
| Never | 40/60 (67) | 39 (57) | 75/307 (24) | 15 (7) | ||
| Past | 4/60 (7) | 11 (16) | 106/307 (35) | 44 (20) | ||
| Current | 16/60 (27) | 19 (28) | 126/307 (41) | 166 (74) | ||
| Smoked ≥1 pack/day, No. (%) | 7/57 (12) | 9/62 (15) | 126/302 (42) | 127/221 (57) | <.001 | .82 |
| History of AP, No. (%)b | 48/61 (79) | 37/66 (56) | 192/295 (65) | 141/207 (68) | .04 | .02 |
| Disability due to CP, No. (%) | 18 (30) | 11 (16) | 51 (17) | 60 (27) | .02 | .10 |
| Calcifications, No. (%) | 28 (46) | 35 (51) | 165 (54) | 140 (62) | .09 | .71 |
| Pseudocysts, No. (%) | 7 (11) | 19 (28) | 73 (24) | 96 (43) | <.001 | .04 |
| Endocrine insufficiency, No. (%) | 18 (30) | 19 (28) | 80 (26) | 67 (30) | .85 | .96 |
| Exocrine insufficiency, No. (%) | 18 (30) | 25 (36) | 108 (35) | 82 (36) | .86 | .53 |
| PERT, No. (%) | 52 (85) | 46 (67) | 205 (67) | 148 (66) | .04 | .02 |
| Antioxidant vitamins, No. (%) | 21 (34) | 20 (29) | 109/307 (36) | 94 (42) | .27 | .63 |
| Pancreatic sphincterotomy, No. (%)c | 14/26 (54) | 10/26 (38) | 58/154 (38) | 32/133 (24) | .02 | .40 |
| Pancreatic duct stent, No. (%) | 31 (51) | 24 (35) | 100 (32) | 63 (28) | .016 | .10 |
| Pancreatic duct stone removal, No. (%) | 6 (10) | 4 (6) | 41 (13) | 30 (13) | .45 | .59 |
| Drainage operations, No. (%) | 4 (7) | 5 (7) | 22 (7) | 17 (8) | ≥99 | ≥99 |
| Partial or complete pancreatectomy, No. (%) | 10 (16) | 15 (22) | 53 (17) | 41 (18) | .91 | .58 |
Abbreviations: ACP, alcohol-related chronic pancreatitis; AP, acute pancreatitis; BMI, body mass index; CP, chronic pancreatitis; EO-ICP, early-onset idiopathic chronic pancreatitis; IQR, interquartile range; LO-ICP, late-onset idiopathic chronic pancreatitis; PERT, pancreatic enzyme replacement therapy; Q1, first quartile; Q3, third quartile.
a
Smoking data not reported for all patients.
b
AP status was never or unclear in remaining patient.
c
Only includes the North American Pancreatitis Studies continuation and validation (NAPS2-CV) study participants.