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. Author manuscript; available in PMC: 2021 Jan 8.
Published in final edited form as: Leukemia. 2020 Apr 1;35(1):177–188. doi: 10.1038/s41375-020-0809-x

Figure 6. Pom upregulates granzyme-B expression via CRBN.

Figure 6.

(a) KHYG-1 cells were transfected with Scsi or CRBNsi. After 48h, cells were cultured in the absence or presence of Pom (0.5 μM) for 24h, and cell lysates immunoblotted with indicated Abs. (b) KHYG-1 cells were transfected with Scsi or Zap-70si, and then cultured for 72h with Pom (0.25 μM), in the absence of IL-2. Cells were counted and incubated with calcein AM-labeled U266 for 4h at indicated effector/target (E/T) ratios. Data are representative two independent experiments and value are expressed in mean ± SD.