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Crystal structures of the WDR5 WIN site detailing ligand guanidino group interactions with arginine and methylarginine isoforms. a. Overview of apo WDR5 with WIN site boxed and magnified. WDR5 complexes with b. L-Arg me0, c. L-Arg me1, d. L-Arg me2s, and e. H3R2me1 peptide ligands. Hydrogen bond (solid line) and p-stack (dashed line) distances are depicted. Water molecule (red sphere). Distances denoted in ångström (Å).
