Table 1:
Demographic and clinical characteristics by failure or success of medical management of early pregnancy loss
| Full cohort N=297 | Failure n=73 | Success n=224 | p-value | |
|---|---|---|---|---|
| Median age (years) | 31 (26–35) | 30 (25–35) | 31 (26–35) | 0.5 |
| Mean BMI (kg/m2) | 27.4 (23.2–32.5) | 27.8 (23.8–32.3) | 27.3 (23.0–32.7) | 0.64 |
| Race | 0.60 | |||
| Black or African American | 131 (44) | 38 (29) | 93 (71) | |
| White | 108 (36) | 25 (23) | 83 (77) | |
| Mixed/more than one race | 30 (10) | 6 (20) | 24 (80) | |
| Asian | 20 (7) | 3 (15) | 17 (85) | |
| Native Hawaiian/Pacific Islander | 2 (1) | 0 (0) | 2 (100) | |
| Other/unknown | 6 (2) | 1 (117) | 5 (83) | |
| Ethnicity | 0.51 | |||
| Non-Hispanic or Non-Latina | 219 (74) | 56 (26) | 163 (74) | |
| Hispanic or Latina | 78 (26) | 17 (22) | 61 (78) | |
| Smoking* | 0.01 | |||
| No | 259 (87) | 57 (22) | 202 (78) | |
| Yes | 37 (13) | 15 (41) | 22 (59) | |
| Prior early pregnancy loss | 0.87 | |||
| No | 193 (65) | 48 (25) | 145 (75) | |
| Yes | 104 (35) | 25 (24) | 79 (76) | |
| Prior induced abortion | 0.40 | |||
| No | 199 (67) | 46 (23) | 153 (77) | |
| Yes | 98 (33) | 27 (28) | 71 (72) | |
| Prior medical abortion* | 0.23 | |||
| No | 274 (93) | 69 (25) | 205 (75) | |
| Yes | 22 (7) | 3 (1) | 19 (86) | |
| Prior surgical abortion* | 0.21 | |||
| No | 202 (68) | 45 (23) | 157 (78) | |
| Yes | 93 (32) | 27 (29) | 66 (71) | |
| Parity | 0.27 | |||
| 0 | 114 (38) | 24 (21) | 90 (79) | |
| 1 or more | 183 (62) | 49 (27) | 134 (73) | |
| Pain during periods | 0.19 | |||
| No pain | 56 (19) | 21 (38) | 35 (62) | |
| Very little | 76 (26) | 14 (18) | 62 (82) | |
| Some | 84 (28) | 20 (24) | 64 (76) | |
| Quite a bit | 35 (12) | 9 (26) | 26 (74) | |
| Very much | 39 (13) | 8 (21) | 31 (79) | |
| Worst pain | 7 (2) | 1 (14) | 6 (86) | |
| Gestational age | 0.75 | |||
| <7 Weeks | 107 (36) | 27 (25) | 80 (75) | |
| 7–8 6/7 Weeks | 144 (48) | 33 (23) | 111 (77) | |
| 9–12 6/7 Weeks | 46 (15) | 13 (28) | 33 (72) | |
| Diagnosis | 0.52 | |||
| Embryonic/fetal demise | 220 (74) | 52 (24) | 168 (76) | |
| Anembryonic gestation | 77 (26) | 21 (27) | 56 (73) | |
| Method of pregnancy conception | 0.13 | |||
| Spontaneous | 276 (94) | 71 (26) | 205 (74) | |
| Assisted reproductive technologies | 16 (5) | 1 (6) | 15 (94) | |
| Active bleeding | 0.74 | |||
| No | 288 (77) | 56 (25) | 172 (75) | |
| Yes | 34 (11) | 7 (21) | 27 (79) | |
| Not assessed | 35 (12) | 10 (29) | 25 (71) | |
| Rh status | 0.94 | |||
| Rh− | 24 (8) | 6 (25) | 18 (75) | |
| Rh+ | 268 (92) | 65 (24) | 203 (76) | |
| Uterine tenderness* | 0.80 | |||
| No | 257 (87) | 62 (24) | 195 (76) | |
| Yes | 11 (4) | 3 (27) | 8 (73) | |
| Not assessed | 27 (9) | 8 (30) | 19 (70) | |
| Randomization arm | 0.001 | |||
| Misoprostol alone | 149 (50) | 49 (33) | 100 (67) | |
| Mifepristone pretreatment | 148 (50) | 24 (16) | 124 (84) | |
| Site | 0.099 | |||
| University of Pennsylvania | 160 (54) | 47 (29) | 113 (71) | |
| University of California, Davis | 76 (26) | 13 (17) | 63 (83) | |
| Albert Einstein College of Medicine | 61 (21) | 13 (21) | 48 (79) |
Data are presented as n (%), mean (standard deviation), or median (interquartile range). Column percentages are presented for the full cohort; row percentages are presented otherwise.
*
Data missing for Smoking (n=1), Prior medical abortion (n=1), Prior surgical abortion (n=2), Rh status (n=5), Uterine tenderness (n=2), Method of pregnancy conception (3)