Fig. 1.
Supplementation of nutritional formula with 2’-FL and 6’-SL protects from disease development in neonatal mice subjected to an experimental model of necrotizing enterocolitis (NEC). ai-iv, ci-ii photomicrographs showing gross morphology, bi-iv, di-ii Haematoxylin-eosin (H&E)-stained images showing histology of small intestine (ileum), e quantitative real-time PCR (qRT-PCR) of pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-α), f NEC severity scores, g nested graph showing body weight changes, in neonatal mice subjected to no treatment (Ctrl, control–breast-fed) or experimental NEC treatments without or with supplementation with lactose (10mg/ml), 2’-FL (10mg/ml/), 6’-SL (10mg/ml), or 2’-FL+6’-SL (5mg/ml, each). **p<0·01, *** p<0·001, each dot in dot-graphs represents data from an individual mouse.