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. Author manuscript; available in PMC: 2021 Feb 14.
Published in final edited form as: Pediatr Res. 2020 Mar 27:10.1038/s41390-020-0852-3. doi: 10.1038/s41390-020-0852-3

Fig. 6. Docking poses of 2’-FL and 6’-SL, and Lactose (LAT) into the eritoran/LPS binding pocket of the TLR4-MD2 complex.

Fig. 6

a CPK model of 2’-FL (cyan carbons) docked to into the x-ray structure of the TLR4-MD2 complex 2Z65, b CPK model of 6’-SL (cyan carbons) docked to into the x-ray structure of the TLR4-MD2 complex 2Z65, c CPK model of Lactose (cyan carbons) docked to into the x-ray structure of the TLR4-MD2 complex 2Z65, d structure of the TLR4-MD2-LPS symmetrical dimer complex 3FXI. The dimerization interface is triggered by LPS (cyan carbons) insertion into the MD2 hydrophobic binding pocket.