Table 5.
Association of type 2 diabetes (T2DM) with changes in functional outcomes after completing 12 weeks of supervised exercise therapy (SET) for the treatment of symptomatic peripheral artery disease (PAD) (n = 44).
| Effect of T2DM | t | p | 95% CI | Model R2 | Marginal Predicted Mean (SD) | ||||
|---|---|---|---|---|---|---|---|---|---|
| Dependent variable | PAD+T2DM | PAD | |||||||
| B | SE | Lower | Upper | (n = 19) | (n = 25) | ||||
| SPPB total score | 0.43 | 0.46 | 0.93 | .358 | −0.50 | 1.36 | .148 | 1.16 (0.53) | 0.63 (0.39) |
| Six-minute walk test | |||||||||
| Claudication onset distance (m) | 58.5 | 27.7 | 2.11 | .044 | 1.6 | 115.4 | .255 | 59.6 (36.5) | 24.3 (30.7) |
| Total distance (m) | −14.0 | 20.6 | −0.68 | .500 | −55.8 | 27.8 | .078 | 18.0 (14.0) | 38.0 (12.3) |
| Percent change in total distance | −20.8 | 17.2 | −1.21 | .236 | −55.7 | 14.2 | .181 | −3.7 (6.9) | 8.8 (7.0) |
| TUG (sec)+ | −0.1 | 0.5 | −0.18 | .857 | −1.1 | 1.0 | −.074 | −0.2 (0.5) | 0.1 (0.5) |
| Treadmill METs | −0.07 | 0.30 | −0.23 | .822 | −0.68 | 0.54 | .179 | 1.14 (0.39) | 1.26 (0.36) |
| WIQ | |||||||||
| Distance | 0.03 | 6.63 | 0.01 | .996 | −13.45 | 13.51 | .130 | 7.48 (8.08) | 7.52 (6.22) |
| Speed | 0.86 | 6.26 | 0.14 | .892 | −11.86 | 13.58 | .145 | 10.87 (7.47) | 10.69 (6.87) |
| Stairs | −1.63 | 7.08 | −0.23 | .820 | −16.01 | 12.76 | .268 | −0.22 (13.95) | 4.34 (9.44) |
| PROMIS-Mobility | −1.6 | 2.3 | −0.12 | .499 | −6.3 | 3.2 | .088 | 1.5 (1.7) | 3.4 (1.8) |
Each row represents an individual multiple linear regression model with the listed variable as the dependent variable and the listed B, SE, t, p, and 95% CI for the effect of T2DM adjusted for age, sex, BMI, ABI, current smoking, history of any peripheral revascularization procedure, and number of exercise sessions completed.
Negative values represent a “desirable” response – decrease in that metric from baseline to follow-up.
ABI, ankle-brachial index; BMI, body mass index; CI, confidence interval; MET, metabolic equivalent of task; PAD+T2DM, peripheral artery disease and comorbid type 2 diabetes mellitus; PROMIS-Mobility, Patient Reported Outcomes Measurement Information System Physical Function Mobility item bank; SPPB, Short Physical Performance Battery; TUG, Timed Up and Go; WIQ, Walking Impairment Questionnaire