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. Author manuscript; available in PMC: 2021 May 4.
Published in final edited form as: Curr Opin Pharmacol. 2020 May 4;51:19–28. doi: 10.1016/j.coph.2020.04.002

Figure 2:

Figure 2:

Class C GPCR Structures. Differing substantially from other GPCR classes, members of the Class C GPCR share a unique structure composed of a very large extracellular domain and the ability to form constitutive dimers, with both homo- and heterodimerization depending on the members, and being obligatory for functionality. A unique extracellular aspect is the Venus flytrap (VFT) domain and highly conserved nine-cysteine residue rich domain (CRD; except for GABABR that lack CRD).