Figure 3.
Influence of CS presentation during reinstatement tests in rats with a history of self-administering MDPV (black bars; n=9) or a mixture of MDPV+caffeine (gray bars; n=6). Filled bars represent CS+drug tests whereas open bars represent drug tests (no CS). Abscissa: CS and no CS refer to the presence (CS+drug test) and absence (drug test) of CS presentation, respectively. The drug and dose (or saline) indicate the pretreatment administered intravenously 5-min before the reinstatement session. Ordinate: total number of responses made on the active lever during the 90-min session. *p<0.05 indicates a significant difference from saline for the same self-administration history and CS condition. #p<0.05 indicates a significant from the CS conditions for the same pretreatment and self-administration history.