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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Addict Biol. 2020 Apr 1;26(2):e12904. doi: 10.1111/adb.12904

Table 1.

Measures of potency (expressed as mg/kg) and effectiveness (expressed as responses / session) in CS+drug reinstatement.

MDPV history MDPV+caffeine history
ED50 Emax ED50 Emax
Mean (95% CI) Mean ± SEM Mean (95% CI) Mean ± SEM
MDPV 0.15 (0.11, 0.20) 308.9 ± 37.1 0.14 (0.10, 0.19) 260.1 ± 27.2
Caffeine 4.30 (3.54, 5.22) 204.7 ± 14.6 3.83 (3.22, 4.55) 229.7 ± 19.7
3:1 MDPV:caffeine 0.18 (0.15, 0.21) 387.4 ± 30.1 # 0.13 (0.11, 0.16) 368.9 ± 43.4 #
1:1 MDPV:caffeine 0.16 (0.15, 0.17) 387.8 ± 26.7 # 0.14 (0.10, 0.18) 406.4 ± 32.0 *#
1:3 MDPV:caffeine 0.15 (0.13, 0.18) 345.8 ± 31.4 # 0.14 (0.13, 0.16) 409.5 ± 28.0 *#
*

p<0.05 indicates a significant difference from the MDPV Emax for the same self-administration history

#

p<0.05 indicates a significant difference from the caffeine Emax for the same self-administration history.