Table 3.
Perinatal outcomes with and without TXA use at delivery.
| Perinatal outcomes | With TXA (n=209) |
Without TXA n=101,355) |
P | aORa (95% CI) | aP |
|---|---|---|---|---|---|
| Blood transfusion | 3 (1.4) | 401 (0.4) | 0.02 | 1.4 (0.4 – 4.7) | 0.56 |
| EBL ≥ 1000 mL | 106 (50.7) | 5,306 (5.2) | <0.0001 | 15.3 (11.1 – 21.1) | <0.0001 |
| ICU admission | 7 (3.3) | 83 (0.1) | <0.0001 | 12.4 (4.9 – 31.7) | <0.0001 |
| VTE | 1 (0.5) | 202 (0.2) | 0.37 | 2.0 (0.3 – 14.6) | 0.49 |
| Chorioamnionitis | 3 (1.4) | 635 (0.6) | 0.14 | 2.0 (0.6 – 6.5) | 0.23 |
| DIC | 2 (1.0) | 12 (<0.1) | <0.0001 | 14.7 (2.4 – 91.1) | 0.004 |
| Placental abruption | 6 (2.9) | 778 (0.8) | 0.0005 | 1.3 (0.5 – 3.5) | 0.58 |
| Placenta accreta | 7 (3.3) | 68 (0.1) | <0.0001 | 13.4 (.1 – 35.2) | <0.0001 |
| NICU admission | 30 (14.4) | 4,343 (4.3) | <0.0001 | 4.3 (2.7 – 6.9) | <0.0001 |
| Vacuum-assisted delivery | 14.0 (6.7) | 6,309 (6.2) | 0.78 | 0.9 (0.5 – 1.6) | 0.79 |
| Forceps-assisted delivery | 2.0 (1.0) | 445 (0.4) | 0.26 | 3.2 (0.8 – 13.0) | 0.11 |
| Eclampsia | 0 (0.0) | 243 (0.2) | 0.48 | - | - |
| HELLP syndrome | 1 (0.5) | 60 (0.1) | 0.013 | 3.2 (0.4 – 25.9) | 0.26 |
| General anesthesia | 5 (9.3) | 657 (0.8) | <0.0001 | 1.5 (0.6 – 4.0) | 0.37 |
CI, confidence interval, EBL, estimated blood loss; ICU, intensive care unit; VTE, venous thromboembolism; DIC, disseminated intravascular coagulation; NICU, neonatal intensive care unit; HELLP, hemolysis, elevated liver enzymes, and low platelets.
a
Adjusted for age, cesarean section, history of postpartum hemorrhage, anemia, placenta previa, and use of magnesium sulfate.