Table 2.
Functional enrichment of MCODE cluster networks of upregulated DEGs highlights GO terms related to cell division and immune system.
| Upregulated DEG clusters | Ontology source | Term ID | GO term | Term P value | FDR |
|---|---|---|---|---|---|
| Cluster-1 | Biological Processes (BP) | GO:0,140,014 | mitotic nuclear division | 1.80 × 10–20 | 9.02 × 10–20 |
| GO:0,000,819 | sister chromatid segregation | 1.17 × 10–17 | 2.92 × 10–17 | ||
| GO:0,007,088 | regulation of mitotic nuclear division | 9.77 × 10–16 | 1.63 × 10–15 | ||
| GO:0,000,070 | mitotic sister chromatid segregation | 3.72 × 10–15 | 2.24 × 10–14 | ||
| GO:0,051,783 | regulation of nuclear division | 4.32 × 10–15 | 1.30 × 10–14 | ||
| Molecular Functions (MF) | GO:0,016,538 | cyclin-dependent protein serine/threonine kinase regulator activity | 1.70 × 10–4 | 2.13 × 10–4 | |
| Cellular Components (CC) | GO:0,000,776 | Kinetochore | 1.07 × 10–10 | 1.80 × 10–10 | |
| GO:0,000,777 | condensed chromosome kinetochore | 3.88 × 10–10 | 1.36 × 10–9 | ||
| GO:0,000,779 | condensed chromosome, centromeric region | 1.12 × 10–9 | 2.63 × 10–9 | ||
| GO:0,005,876 | spindle microtubule | 7.48 × 10–8 | 9.36 × 10–8 | ||
| GO:0,000,307 | cyclin-dependent protein kinase holoenzyme complex | 7.84 × 10–5 | 1.09 × 10–4 | ||
| KEGG Pathways (KP) | KEGG:04,110 | Cell cycle | 2.08 × 10–10 | 3.47 × 10–10 | |
| KEGG:04,114 | Oocyte meiosis | 8.49 × 10–7 | 1.70 × 10–6 | ||
| KEGG:04,914 | Progesterone-mediated oocyte maturation | 1.29 × 10–5 | 2.07 × 10–5 | ||
| KEGG:04,115 | p53 signaling pathway | 1.74 × 10–4 | 1.74 × 10–4 | ||
| Cluster-2 | Biological Processes (BP) | GO:0,071,346 | cellular response to interferon-gamma | 2.84 × 10–14 | 1.42 × 10–13 |
| GO:0,060,333 | interferon-gamma-mediated signaling pathway | 1.78 × 10–12 | 4.45 × 10–12 | ||
| GO:0,071,357 | cellular response to type I interferon | 1.80 × 10–8 | 2.52 × 10–8 | ||
| GO:0,060,337 | type I interferon signaling pathway | 1.80 × 10–8 | 2.52 × 10–8 | ||
| GO:0,034,340 | response to type I interferon | 2.27 × 10–8 | 6.81 × 10–8 | ||
| Molecular Functions (MF) | GO:0,048,248 | CXCR3 chemokine receptor binding | 9.28 × 10–9 | 4.64 × 10–8 | |
| GO:0,045,236 | CXCR chemokine receptor binding | 1.32 × 10–7 | 2.20 × 10–7 | ||
| GO:0,042,379 | chemokine receptor binding | 7.92 × 10–7 | 1.43 × 10–6 | ||
| GO:0,008,009 | chemokine activity | 1.96 × 10–5 | 2.53 × 10–5 | ||
| KEGG Pathways (KP) | KEGG:05,133 | Pertussis | 1.21 × 10–5 | 1.52 × 10–5 | |
| KEGG:05,140 | Leishmaniasis | 3.83 × 10–4 | 3.83 × 10–4 | ||
| Immune System Processes (ISP) | GO:0,071,346 | cellular response to interferon-gamma | 2.30 × 10–8 | 5.77 × 10–8 | |
| GO:0,060,333 | interferon-gamma-mediated signaling pathway | 7.28 × 10–8 | 9.11 × 10–8 | ||
| GO:0,071,357 | cellular response to type I interferon | 3.31 × 10–5 | 6.63 × 10–5 | ||
| GO:0,060,337 | type I interferon signaling pathway | 3.31 × 10–5 | 6.63 × 10–5 | ||
| GO:0,034,340 | response to type I interferon | 4.15 × 10–5 | 4.98 × 10–5 |