Table 3.
Functional enrichment of MCODE cluster networks of downregulated DEGs highlights GO terms related to mineral absorption and metabolism.
| Down-regulated DEG modules | Ontology Source | Term ID | GO Term | Term PValue | FDR |
|---|---|---|---|---|---|
| Cluster-1 | Biological Processes (BP) | GO:1,990,169 | stress response to copper ion | 9.10 × 10–21 | 1.00 × 10–19 |
| GO:0,061,687 | detoxification of inorganic compound | 1.44 × 10–20 | 7.21 × 10–20 | ||
| GO:0,097,501 | stress response to metal ion | 2.21 × 10–20 | 5.55 × 10–20 | ||
| GO:0,071,294 | cellular response to zinc ion | 1.88 × 10–19 | 5.17 × 10–19 | ||
| GO:0,071,276 | cellular response to cadmium ion | 1.09 × 10–17 | 2.41 × 10–17 | ||
| KEGG Pathways (KP) | KEGG:04,978 | Mineral absorption | 3.45 × 10–15 | 5.75 × 10–15 | |
| Cluster-2 | Biological Processes (BP) | GO:0,006,721 | terpenoid metabolic process | 1.82 × 10–7 | 1.82 × 10–7 |
| GO:0,050,892 | intestinal absorption | 1.30 × 10–6 | 4.56 × 10–6 | ||
| GO:0,035,376 | sterol import | 1.64 × 10–6 | 2.00 × 10–6 | ||
| GO:0,070,508 | cholesterol import | 1.63 × 10–6 | 1.80 × 10–6 | ||
| GO:0,034,371 | chylomicron remodeling | 2.04 × 10–6 | 1.84 × 10–5 | ||
| Molecular Functions (MF) | GO:0,072,349 | modified amino acid transmembrane transporter activity | 2.20 × 10–5 | 3.08 × 10–5 | |
| GO:0,050,660 | flavin adenine dinucleotide binding | 2.39 × 10–5 | 4.31 × 10–5 | ||
| GO:0,016,712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | 2.89 × 10–5 | 4.34 × 10–5 | ||
| GO:0,008,395 | steroid hydroxylase activity | 3.42 × 10–5 | 4.41 × 10–5 | ||
| GO:0,005,310 | dicarboxylic acid transmembrane transporter activity | 1.26 × 10–4 | 1.26 × 10–4 | ||
| Cellular Components (CC) | GO:0,042,627 | Chylomicron | 3.69 × 10–6 | 8.61 × 10–6 | |
| GO:0,034,385 | triglyceride-rich plasma lipoprotein particle | 1.10 × 10–5 | 1.84 × 10–5 | ||
| GO:0,034,361 | very-low-density lipoprotein particle | 1.10 × 10–5 | 1.93 × 10–5 | ||
| GO:0,034,364 | high-density lipoprotein particle | 2.90 × 10–5 | 4.84 × 10–5 | ||
| GO:0,034,358 | plasma lipoprotein particle | 7.66 × 10–5 | 9.58 × 10–5 | ||
| KEGG Pathways (KP) | KEGG:03,320 | PPAR signaling pathway | 1.46 × 10–7 | 1.17 × 10–6 | |
| KEGG:05,204 | Chemical carcinogenesis | 2.72 × 10–7 | 1.09 × 10–6 | ||
| KEGG:04,977 | Vitamin digestion and absorption | 1.14 × 10–6 | 8.00 × 10–6 | ||
| KEGG:00,980 | Metabolism of xenobiotics by cytochrome P450 | 5.17 × 10–6 | 1.03 × 10–5 | ||
| KEGG:04,979 | Cholesterol metabolism | 2.33 × 10–5 | 2.71 × 10–5 |