Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
PK parameters of 100 mg/kg antibody in mice determined by the 2-compartment model.
| Parameter | Unit | Mean | CV% |
|---|---|---|---|
| V1 | mL/kg | 25.7 | 11.3 |
| k10 | 1/day | 2.46 | 11.4 |
| k12 | 1/day | 14.2 | 74.1 |
| k21 | 1/day | 25.3 | 57.5 |
The mean plasma concentration–time profile of the antibody at 100 mg/kg was analyzed by the 2-compartment model, and the target-independent PK parameters k10, k12, k21, and V1 were estimated.
